Welcome!

Cancer Vaccines Advance to Phase IIb

Posted: October 23rd, 2012 | Author: | Filed under: Passport Health Sarasota-Bradenton Announcements | Tags: , , , , , | Comments Off on Cancer Vaccines Advance to Phase IIb

CureVac, a biotech company pushing therapeutic cancer vaccinesinto Phase IIb studies, landed a cool $104 million from German multibillionaire Dietmar Hopp’s investment group, Dievini Hopp BioTech Holding.

Image representing CureVac as depicted in Crun...

Image via CrunchBase

Image representing dievini Hopp Biotech Holdin...

Image via CrunchBase

CureVac will use the hefty sum to advance the development of its two lead RNActive cancer vaccines against prostate cancer and non-small cell lung cancer.  The company will also use some of the funds to further develop its prophylactic vaccines and adjuvants for infectious diseases.  The first task will be to run a Phase IIb study on prostate cancer vaccine CV9103, CureVac CEO Ingmar Hoerr told FierceBiotech.

To date, CureVac has raked in about €145 million ($189 million) in equity financing.

“Our technology is based on a major new understanding of the medical potential of mRNA, and our novel mRNA vaccines and RNA-based adjuvants may transform the treatment of many debilitating diseases, including prostate and lung cancer, as well as the prophylaxis of many infectious diseases,” Hoerr said.

Last September, CureVac and Sanofi Pasteur inked a deal to develop and apply the RNActive technology platform to the development of vaccines against several infectious diseases.  In another deal, the two companies–along with France’s In Cell Art–undertook a $33 million DARPA research program to identify and create a universal vaccine technology platform for infectious diseases.

Enhanced by Zemanta

Breakthrough in the Search for a Malaria Vaccine

Posted: September 20th, 2012 | Author: | Filed under: Passport Health Sarasota-Bradenton Announcements | Tags: , , , , , , , | Comments Off on Breakthrough in the Search for a Malaria Vaccine

Researchers atAustralia’s Burnet Institute discovered a prime target in the immune system’s battle against malaria, marking a turning point in the search for a vaccine.

Malaria distribution map. Most countries with ...

Malaria distribution map. Most countries with a high distribution of malaria also have a high distribution of parasitic worm infections. (Photo credit: Wikipedia)

Studies show people immune to the disease develop antibodies that home in on a protein known as PfEMP1, produced by Plasmodium falciparum, the organism behind most cases of malaria, according to Medical Xpress. The findings prove valuable in determining for which malaria proteins–known as variant surface antigens–a vaccine should aim. The study also showed that when the immune system takes action against other proteins produced by malaria, it does not effectively protect the body, further underscoring the need for a vaccine to seek out the appropriate target.

“The new findings support the idea that a vaccine could be developed that stimulates the immune system so that it specifically mounts a strong response (or attack) against the PfEMP1 protein that malaria produces,” James Beeson, senior author of the study, tells Medical Xpress.

More than 40% of the world’s population live in areas where there is a risk of contracting the mosquito-borne illness, which will make developing a vaccine both profitable to the manufacturer and beneficial to world health. Nearly 1 million individuals die of malaria each year, according to the NIH.